



Medical Abortion: 3 to 9 Weeks with the use of Methotrexate
medical abortions have become popular in the U.S. Since 2001 the FDA approval of RU 486 for pregnancy from 3 to 7 weeks. Before 2001, a> were carried out usually with methotrexate. Methtrexate was approved by the FDA in late 1950 for the treatment of certain cancers. Since then it has been used to treat psoriasis and rheumatoid arthritis.
Methotrexate is known to cause serious miscarriages and fetal abnormalities in the first trimester of pregnancy (up to 12 weeks of gestation). Patients diagnosed as pregnant women delay treatment for their particular disease, even after delivery, or choose to undergo an abortion, especially in the first trimester of pregnancy.
In the mid 80′s, there was extensive research documented in medical literaturethat discuss the treatment of tubal ectopic pregnancy (pregnancy outside the uterus). Methotrexate targets and destroys certain parts of the pregnancy tissue (trophoblast) necessary for fetal growth. Without the trophoblastic tissue, the tissue of pregnancy reduced in size and disappears preventing the need for surgery.
has been observed in patients less than 6 weeks of gestation takes 25-30 days after receiving methotrexate, for the uterus begin to contract and expel the pregnancy tissue . In order to reduce the length it took to complete the abortion process, Cytotec (misoprostol) was added. Cytotec is a prostaglandin known to cause uterine contractions. The changes are also produced locally in the cervix (lower part of the womb) to allow the cervix to dilate (open) and become sweet and soft tissue causes the pregnancy to be expelled from the uterus. This process can last on average between 1 and 14 days to complete. Some patients may take longer. On average, there is a rate of 5-12% failure using the combination of methotrexate and cytotec for carrying out the abortion procedure in patients between 3 and 9 weeks pregnant. Patients less than 6 weeks’ gestation have a rate of 97-99% success. In essence, the beginning of pregnancy, the medical abortion procedure is performed, the greater the success rate.
Abortions cytotec methotrexate and is associated with few complications. Given the small dose of methotrexate used, there are minimal side effects. These inculde the possibility of cystitis (bladder irritation) a rash with excessive sun exposure. Hair loss and low blood cell counts were not observed in our clinical practice. Other advantages of methotrexate is that it is expensive to use, and can be administered by injection or by mouth. For patients who are unable to contain liquids or food because of nausea and vomiting, giving intramuscular methotrexate is an excellent choice.
The complications associated with the procedure of abortion, generally canned (tissue left behind in the uterus) or failure of the procedure, persistent or excessive bleeding, all of which require a
In conclusion, medical abortion with methotrexate and Cytotec has been used for many years to end pregnancies up to nine weeks of gestation. Although not as effective as RU486 after 6 weeks of gestation to terminate the pregnancy, has been found to be as effective in patients less than six weeks. . For patients who are allergic to the pill RU486, unable to swallow pills that are experiencing nausea and vomiting, or have other contraindications including adrenal insufficiency, the use of methotrexate is a viable alternative. P>
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